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Alan Franciscus
Editor-in-Chief
HCV Advocate
HBV Advocate

Monday, October 22, 2012

New Hepatitis B Vaccine Induces Higher Seroprotection Rates Than Engerix-B

SAN DIEGO, CA—Two doses of the investigational hepatitis B vaccine, HEPLISAV, administered over 4 weeks induced significantly higher rates of and earlier seroprotection than Engerix-B given as 3 doses over 24 weeks, results of two pivotal Phase 3 trials concluded at IDWeek 2012.

Two multicenter trials of the two vaccines were conducted to determine immunogenicity in subjects in the age range for the proposed indication for HEPLISAV, noted Robert Janssen, MD, from Dynavax Technologies, Berkeley, CA. Dynavax has submitted a Biologics License Application to the U.S. Food and Drug Administration for an indication of prevention of hepatitis B infection in individuals 18 to 70 years old.

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