Welcome to HCV Advocate’s hepatitis blog. The intent of this blog is to keep our website audience up-to-date on information about hepatitis and to answer some of our web site and training audience questions. People are encouraged to submit questions and post comments.

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Alan Franciscus
HCV Advocate

Saturday, September 22, 2012

Switching to tenofovir suppresses hepatitis B in HIV/HBV co-infected people

People with HIV and hepatitis B virus (HBV) co-infection, who substituted tenofovir (Viread) for zidovudine (Retrovir) or abacavir (Ziagen) in their antiretroviral regimen, saw a reduction in hepatitis B viral load despite HBV being resistant to lamivudine (Epivir), according to a poster presented at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) last week in San Francisco.

Some antiretroviral drugs, including tenofovir and lamivudine, are also active against hepatitis B virus. European and US treatment guidelines recommend that people with HIV/HBV co-infection should include at least one of these drugs in their antiretroviral regimen. Hepatitis B virus rapidly develops resistance to lamivudine, however, which may compromise its effectiveness.


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