Scientists at the Genome Institute of Singapore (GIS) have
unraveled the mechanism that causes liver cancer (hepatocellular
carcinoma, HCC), one of the most common solid tumors worldwide. This
genome-wide research was done in collaboration with colleagues from the
National University of Singapore (NUS), University of Hong Kong, Eli
Lilly & Co. USA, Merck Research Laboratories USA, Pfizer Oncology
USA and Beijing Genomics Institute China.
The discovery was published in the prestigious scientific journal, Nature Genetics,
on 27 May 2012. The GIS is a research institute under the umbrella of
the Agency for Science, Technology and Research (A*STAR).
One major cause of liver cancer,
or HCC, is high exposure to the hepatitis B virus (HBV), resulting in
the integration of HBV into the victim’s genes. Individuals who carry
the HBV have a greater than 100-fold increased relative risk of
developing HCC, considered to be a serious global health problem by the
World Health Organization (WHO).
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